If a new rapid test for a virulent bacterial infection requires a balance of sensitivity and specificity, what cutoff point would maximize sensitivity?

To maximize sensitivity in a diagnostic test, the cutoff point is set at a level that allows for the highest number of true positive results. Sensitivity is defined as the ability of a test to correctly identify those with the disease (true positives) out of all those who actually have the disease (true positives + false negatives). Therefore, the cutoff point that yields the highest sensitivity is typically located at a threshold where most cases of the disease will test positive, even if it means that there may be an increase in false positives.

Choosing a lower cutoff point generally allows more individuals who have the disease to be identified; this can be critical in managing virulent infections where early detection is crucial. By doing so, the test would reduce the number of false negatives—individuals who have the infection but are incorrectly classified as healthy. Thus, if the question identifies that setting the cutoff at Point B maximizes sensitivity, it indicates that Point B is likely the threshold where the test correctly identifies the majority of true cases without significant missed diagnoses. This is particularly important in the context of a virulent bacterial infection, where timely identification can greatly impact treatment outcomes and public health measures.