In a patient with allergic rhinitis, which type of cells are likely to be increased in nasal secretions?

In the context of allergic rhinitis, eosinophils are particularly significant because they play a crucial role in the allergic response. When an individual with allergic rhinitis is exposed to allergens, such as pollen or pet dander, a hypersensitivity reaction occurs. This reaction typically leads to the activation of T-helper cells, which in turn stimulate B cells to produce IgE antibodies. IgE binds to mast cells and basophils, causing them to release inflammatory mediators.

During this process, eosinophils are attracted to the site of inflammation by various chemokines and cytokines released during the allergic reaction. Once they arrive, eosinophils can contribute to tissue damage and inflammation via the release of their own mediators, including leukotrienes, prostaglandins, and major basic protein. The presence of increased eosinophils in nasal secretions is a hallmark of allergic inflammation and indicates ongoing allergic processes.

This increase can be assessed through nasal swabs or aspirates, which can show eosinophilia, further confirming the diagnosis of allergic rhinitis and helping to distinguish it from other forms of nasal inflammation. Overall, the elevated eosinophil count in nasal secretions is a clear indicator of the type and severity