What condition presents with a deficiency in chloride channels leading to recurrent infections and malabsorption?

Cystic fibrosis is a genetic disorder characterized by a defect in the CFTR gene, which encodes for a chloride channel. This deficiency in chloride channels leads to the production of thick, sticky mucus in various organs, particularly the lungs and the pancreas. The thick mucus obstructs airways and creates an environment conducive to recurrent bacterial infections in the lungs, as it is difficult for the body to clear out pathogens.

Additionally, the obstruction of pancreatic ducts results in insufficient delivery of digestive enzymes into the intestines, leading to malabsorption of nutrients. This malabsorption manifests as difficulties in digestion and absorption, often resulting in nutrient deficiencies and failure to thrive in affected individuals.

The other conditions listed do not primarily involve a deficiency of chloride channels nor are they associated with the same respiratory and gastrointestinal problems seen in cystic fibrosis.