What neurotransmitter is primarily involved in the treatment of acute migraines?

The primary neurotransmitter involved in the treatment of acute migraines is serotonin. During a migraine attack, there are significant changes in the levels of serotonin in the brain, and this neurotransmitter plays a crucial role in vasoconstriction and modulation of pain. Many of the medications used to treat acute migraines, such as triptans, work by agonizing serotonin receptors, specifically the 5-HT1B and 5-HT1D subtypes. These medications help alleviate migraine symptoms by constricting dilated blood vessels in the brain and inhibiting the release of pro-inflammatory peptides that contribute to the pain and discomfort associated with migraines. This specific mechanism underscores the importance of serotonin in effectively managing acute migraine episodes.