What structural component is likely absent in patients with Zellweger syndrome?

Zellweger syndrome is a genetic disorder that falls under the category of peroxisome biogenesis disorders. This condition is characterized by the absence or malfunctioning of peroxisomes, which are organelles responsible for various metabolic processes, including the breakdown of very long-chain fatty acids, the detoxification of hydrogen peroxide, and the metabolism of other lipids.

In patients with Zellweger syndrome, the mutations in genes involved in peroxisome formation lead to the inability to produce functional peroxisomes. As a result, affected individuals exhibit various clinical manifestations, such as neurological impairment, hepatomegaly, and distinctive facial features.

Consequently, the structural component that is likely absent in patients with Zellweger syndrome is indeed peroxisomes, confirming the correctness of the answer. This condition illustrates the vital role that peroxisomes play in human health and metabolism, and their absence is central to the pathology of Zellweger syndrome.