Which of the following cells is primarily involved in the late phase of an allergic response?

The late phase of an allergic response is characterized by the influx and activation of inflammatory cells that contribute to sustained allergic reactions. Eosinophils play a crucial role in this phase. After the initial allergic reaction, which is predominantly mediated by mast cells and their release of histamine and other mediators, eosinophils migrate to the site of inflammation.

They are attracted by various chemotactic factors, including those released by mast cells and T lymphocytes, and they contribute to tissue inflammation, damage, and remodeling. Eosinophils release inflammatory mediators such as leukotrienes, prostaglandins, and cytokines, which help perpetuate the allergic response and can cause tissue damage as they accumulate in affected areas.

While basophils, lymphocytes, and mast cells are all involved in the immune response, they have different roles, particularly in the initial phase of the reaction or in other types of immune responses. Mast cells are primarily involved in the immediate hypersensitivity reaction, while basophils contribute to the early phase of the response. Lymphocytes, particularly T-helper cells, are involved in orchestrating the immune response but are not the primary players in the late phase of an allergic response.