Which of the following enzymes increases in the liver due to insulin administration in diabetic ketoacidosis?

Insulin administration in diabetic ketoacidosis leads to an increase in the activity of glucokinase in the liver. Glucokinase plays a crucial role in glucose metabolism by catalyzing the phosphorylation of glucose to glucose-6-phosphate, which is a key step that facilitates the conversion of glucose into forms that can be stored or utilized for energy.

In the context of diabetic ketoacidosis, insulin serves to reduce blood glucose levels by promoting glucose uptake in peripheral tissues and enhancing hepatic glucose storage. When insulin is administered, it stimulates the expression and activity of glucokinase, thereby encouraging the liver to convert more glucose into glucose-6-phosphate. This effect helps to lower the elevated blood glucose levels characteristic of hyperglycemia in diabetic patients.

On the other hand, enzymes such as glycogen phosphorylase, phosphoenolpyruvate carboxykinase, and glucose 6-phosphatase do not increase in the liver with insulin administration. Instead, they are involved in pathways that promote gluconeogenesis and glycogen breakdown, which are generally inhibited by insulin in order to facilitate the uptake and storage of glucose.